Syllabus Information

5.1. Methodological overview

The methodology followed in this course is oriented towards achievement of the learning objectives. It favors the acquisition of knowledge related to Physiology. A wide range of teaching and learning tasks are implemented, such as lectures, practice sessions, and assignments.

Students are expected to participate actively in the class throughout the semester.

Classroom materials will be available via Moodle. These include a repository of the lecture notes used in class, the course syllabus, as well as other course-specific learning materials.

Further information regarding the course will be provided on the first day of class.

5.2. Learning tasks

The course includes 6 ECTS organized according to:

- Lectures

- Practice sessions

- Seminars

- Clinical problem-solving

- Autonomous work

5.3. Syllabus

THEORETICAL PROGRAM

RENAL PHYSIOLOGY

1.Homeostasis and Renal Function

2. General structure and functions of the kidney.

3. Glomerular ultrafiltration. Concept of clearance.

4. Reabsorption and tubular secretion. Concept of Tm.

5. Osmotic activity of the kidney.

6. Regulation of water balance. Regulation of osmolarity.

7. Balance and distribution of sodium, chloride ions. Renal management of sodium and chlorine. Regulation of your balance.

Renin-All-Aldosterone System. Renal regulation of the extracellular volume.

8. Balance and distribution of potassium. Renal potassium management. Regulation of the balance and distribution.

9. Balance and distribution of calcium phosphorus and magnesium. Its Renal Management. Regulation of the balance.

10. Renal regulation of acid-base equilibrium.

11. Functions of the bladder and urinary tract.

FUNCTIONAL HEMATOLOGY

12. General characteristics and functions of blood.

13. Plasma components and functions.

14. Red blood cells: features and functions.

15. Erythropoiesis and its regulation. Iron metabolism.

16. Red cell antigens.

17. Types and functions of leukocytes, Leucopoyesis.

18. Physiological haemostasis. Vascular responses. Functions of platelets.

19. Blood clotting. Activation and regulation of coagulation.

20. Physiological fibrinolysis. Mechanisms of anticoagulation. Functional tests of hemostasis.

IMMUNE SYSTEM

21. The immune system. Structure and organization of the immune system. Inborn immunity and adaptive immunity.

Main components of the immune system. Panoramic view of the immune response.

22. Innate immune response. Regulation of the activation. Cells and soluble factors. The complement.

23. Regulation of cellular activation and migration during the immune response: Cytokines, chemokines and adhesion molecules

24. Adaptive immune response. The B lymphocyte

25. Immunoglobulins. Structure and Function

26. Adaptive immune response. The helper T lymphocyte.

27. HLA system. Routes of antigenic presentation. Dendritic cells.

28. Cytotoxic response. Cytotoxic T lymphocytes and NK cells. Cell death.

29. Immune tolerance. Regulation of the immune response. Development, evolution and aging of the immune system.

30. Initiation to immunotherapy. Pharmacological modulation of the immune response in infection and cancer.

PRACTICE PROGRAM IN ZARAGOZA

Urine Concentration-Dilution Test

Urine analysis. Urinary sediment

Functional problem in "Hypernatremia"

Functional problem in "Hemostasis"

Blood extraction

Sedimentation Rate

Blood groups

Hematocrit

Coagulation time and Prothrombin time

Osmotic resistance and haemolysis

Leukocyte Formula by Flow Cytometry

Collection of platelet-rich plasma and its determination by cytometry

Collection of platelet-rich plasma and its determination by cytometry

Synthesis of antibodies and application to diagnosis (seminar)

Manipulation of cellular immunity in cancer (seminar)

Separation of lymphocytes

Study of cellular morphology

Agglutination reaction

PRACTICE PROGRAM IN HUESCA

Urine Concentration-Dilution Test

Urine analysis. Urinary sediment

Problem-Based Learning (ABP): Kidney

Blood Groups and Hematocrit

Simulation of blood extraction, velocity of sedimentation.

ABP: Hematological Blood-Constants

Leukocyte Formula and Lymphocyte Separation

Seminar Immunology o Study of cellular morphology

5.4. Course planning and calendar

For further details concerning the timetable, classroom and further information regarding this course please refer to the "Facultad de Medicina" website (http://www.unizar.es/estructura/facultades-y-escuelas/facultad-de-medicina)